Current Approaches in Glomerular Diseases

This book comprehensively covers current approaches and management strategies for glomerular diseases. It provides detailed insights into the pathogenesis, clinical manifestations, diagnosis, and treatment of key glomerular diseases including membranous nephropathy, IgA nephropathy, anti-glomerular basement membrane disease, membranoproliferative glomerulonephritis, and ANCA-associated glomerulonephritis. Membranous nephropathy is characterized by immune complex deposition with anti-PLA2R antibodies playing a key diagnostic and therapeutic role. IgA nephropathy follows a multi-hit pathophysiology with treatments including renin-angiotensin system blockers, SGLT2 inhibitors, and immunomodulators. Anti-GBM disease involves severe autoimmune injury causing rapidly progressive glomerulonephritis and alveolar hemorrhage, managed primarily with plasma exchange, cyclophosphamide, and glucocorticoids. Membranoproliferative GN is divided into immune complex-mediated and complement-mediated types, with emerging complement inhibitors offering promising treatment avenues. ANCA-associated GN treatment centers on rituximab and cyclophosphamide, with Avacopan as a steroid-sparing option. The book also thoroughly examines monoclonal gammopathy of renal significance (MGRS), emphasizing early diagnosis, clone-directed therapies, and the importance of a multidisciplinary approach. Overall, the text aims to improve patient outcomes through advanced therapeutic strategies and integrated care.