Frontiers in cardiovascular medicine: Imaging, molecular mechanisms, pharmacotherapy, and surgical protection

This book comprehensively addresses four key areas in cardiovascular medicine: phenotype-based multimodality imaging in cardiomyopathies, the role of microRNAs in myocardial ischemia-reperfusion injury, current approaches to the use of SGLT2 inhibitors in heart failure, and the status of myocardial protection in cardiac surgery. It details the diagnostic and prognostic contributions of imaging techniques including echocardiography, cardiac magnetic resonance, computed tomography, and nuclear imaging, emphasizing their integrated application in cardiomyopathy care. The role of miRNAs in regulating cardiomyocyte survival and apoptosis during ischemia-reperfusion injury is explored, highlighting potential therapeutic targets. The evolving use of SGLT2 inhibitors in heart failure management is reviewed with respect to mechanism, patient selection, dosage, side effect monitoring, and special populations, supported by recent clinical trials. Myocardial protection in cardiac surgery is discussed focusing on cardioplegic solutions, genetic and molecular impacts, and ongoing challenges. Overall, the work serves as a comprehensive reference for cardiologists, cardiac surgeons, and healthcare professionals, combining foundational science and practical clinical guidance to advance cardiovascular disease diagnosis and treatment.