Veteriner Klinik Biyokimyada Yenilikçi Gelişmeler

This book encompasses innovative developments in veterinary clinical biochemistry, divided into three main sections. The first section delves into the significance of enzymes in clinical biochemistry of cats and dogs, elaborating on the measurement, mechanisms, and clinical interpretations of various serum enzymes such as Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Sorbitol Dehydrogenase (SDH), Glutamate Dehydrogenase (GDH), Gamma Glutamyl Transferase (GGT), Alkaline Phosphatase (ALP), Lipase, Amylase, and Creatine Kinase (CK). It discusses how alterations in enzyme levels assist in diagnosing organ dysfunctions, disease differentiation, and monitoring treatment responses. The second section addresses acute phase proteins (APPs) as biochemical markers in animal diseases, focusing on positive and negative APPs such as Serum Amyloid A (SAA), Haptoglobin (Hp), C-Reactive Protein (CRP), Ceruloplasmin, Fibrinogen, α1-Acid Glycoprotein (AGP), α1-Antitrypsin, and α2-Macroglobulin. Their roles in inflammatory responses, species-specific expressions, and clinical applications are thoroughly examined. The third section provides an extensive review of matrix metalloproteinases (MMPs) and their critical functions in cancer. It covers MMP structures, classifications, and regulatory roles in extracellular matrix remodeling, tumor microenvironment, angiogenesis, and metastasis. The involvement of MMPs in various cancers including prostate, skin, ovarian, cervical, lung, and gastric cancers is detailed, highlighting their prognostic and therapeutic potentials. Additionally, the section explores MMP activity in veterinary species such as dogs, cats, horses, and ruminants, underscoring their diagnostic and prognostic biomarker values in pathological conditions. Overall, this comprehensive work offers valuable insights and practical perspectives in veterinary clinical biochemistry.